NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System
HHS-NIH11 Forecasted RFA-DA-27-012Description
The NIH Blueprint (a consortium of NIH Institutes that support neuroscience research) seeks to advance its mission by supporting the development, optimization, validation, and application of germline and somatic transgenic and gene-editing approaches in experimental systems modeling key features of human brain anatomy, circuitry, cognition, behavior, and lifespan. This initiative will build on the previously supported marmoset gene-editing infrastructure, by integrating New Approach Methodologies (NAMs) with other models, to advance understanding of human brain function and disease, including human-derived NAMs for cross-species comparisons across development. Many mechanisms of complex conditions, such as autism spectrum disorders, schizophrenia, and other behavioral/developmental disorders, cannot yet be captured in NAMs and are therefore high priorities for research investment to accelerate development and validation of human-derived NAMs. Appropriate models should be used and clearly justified as necessary for questions involving neuroanatomy, circuit function, cognition, behavior, or lifespan phenotyping related to human brain disease and function. Grant authorities are as follows: 42 U.S.C 241 and 284.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Actions
Funding Details
- Award Floor
- Not specified
- Award Ceiling
- $1,200,000.00
- Total Estimated Funding
- $7,200,000.00
- Expected Awards
- 4
Key Dates
- Posted
- May 7, 2026
- Closes
- N/A
- Archive Date
- N/A
Agency Information
- Agency Name
- National Institutes of Health
- Agency Code
- HHS-NIH11
- Funding Instrument
- Other